UNC5D anticorps (AA 112-200) (Alexa Fluor 555)
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- Antigène Voir toutes UNC5D Anticorps
- UNC5D (Unc-5 Homolog D (UNC5D))
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Épitope
- AA 112-200
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp UNC5D est conjugé à/à la Alexa Fluor 555
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human UNC5H4
- Isotype
- IgG
- Top Product
- Discover our top product UNC5D Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- UNC5D (Unc-5 Homolog D (UNC5D))
- Autre désignation
- UNC5D/UNC5H4 (UNC5D Produits)
- Synonymes
- anticorps UNC5D, anticorps PRO34692, anticorps Unc5h4, anticorps D930029E11Rik, anticorps mKIAA1777, anticorps unc-5 netrin receptor D, anticorps unc-5 homolog D (C. elegans), anticorps Unc5d, anticorps UNC5D, anticorps unc5d
- Sujet
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Synonyms: Netrin receptor UNC5D, Netrin receptor Unc5h4, Protein unc 5 homolog D, Unc 5 homolog 4, Unc 5 homolog D C. elegans, Unc 5 homolog D, UNC 5D, Unc5h4, FLJ16019, KIAA1777.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
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