APBB3 anticorps (AA 401-486) (Alexa Fluor 555)

N° du produit ABIN1392449

Détail du produit anti-APBB3 anticorps (Alexa Fluor 555)

Antigène: APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))

Épitope: AA 401-486

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APBB3 est conjugé à/à la Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human APBB3/FE65L2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur APBB3

Antigène: APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))

Autre désignation: APBB3/FE65L2 (APBB3 Produits)

Synonymes: anticorps Fe65l2, anticorps Rirl2, anticorps TR2S, anticorps MGC142933, anticorps FE65L2, anticorps SRA, anticorps amyloid beta (A4) precursor protein-binding, family B, member 3, anticorps steroid receptor RNA activator 1, anticorps amyloid beta precursor protein binding family B member 3, anticorps Apbb3, anticorps SRA1, anticorps APBB3, anticorps apbb3

Sujet:

Synonyms: Amyloid beta A4 precursor protein binding family B member 3, Amyloid beta A4 precursor protein-binding family B member 3, amyloid beta precursor protein binding family B member 3, amyloid precursor interacting protein, Apbb3, APBB3_HUMAN, Fe65 like protein 2, FE65L2, Protein Fe65-like 2, SRA.

Background: Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the -Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of -Amyloid. Via its ability to control the intracellular accumulation of -Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6 % of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

ID gène: 10307

UniProt: O95704