Calsyntenin 1 anticorps (AA 501-600) (Alexa Fluor 488)

N° du produit ABIN1392490

Détail du produit anti-Calsyntenin 1 anticorps (Alexa Fluor 488)

Antigène: Calsyntenin 1 (CLSTN1)

Épitope: AA 501-600

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calsyntenin 1 est conjugé à/à la Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Calsyntenin 1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Calsyntenin 1

Antigène: Calsyntenin 1 (CLSTN1)

Autre désignation: CLSTN1/Calsyntenin 1 (CLSTN1 Produits)

Synonymes: anticorps CALSYNTENIN-1, anticorps fm67g03, anticorps wu:fk52g02, anticorps wu:fm67g03, anticorps zgc:153744, anticorps zgc:56528, anticorps clstn1, anticorps 1810034E21Rik, anticorps Cst-1, anticorps Cstn1, anticorps ALC-ALPHA, anticorps CDHR12, anticorps CSTN1, anticorps PIK3CD, anticorps XB31alpha, anticorps alcalpha1, anticorps alcalpha2, anticorps calsyntenin 1, anticorps calsyntenin 3, anticorps beta-catenin-interacting protein 1, anticorps calsyntenin-1, anticorps CLSTN1, anticorps clstn1, anticorps clstn3, anticorps LOC100356725, anticorps LOC100435584, anticorps Clstn1, anticorps LOC479600

Sujet:

Synonyms: Alc alpha, Alc-alpha, Alcadein alpha 1, Alcadein alpha, Alcadein-alpha, alcalpha1, alcalpha2, Alzheimer related cadherin like protein, Alzheimer-related cadherin-like protein, Calsyntenin-1, Calsyntenin1, CLSTN 1, Clstn1, CS1, CSTN1, CSTN1_HUMAN, CTF1-alpha, FLJ32258, KIAA0911, Non classical cadherin XB31alpha, Non-classical cadherin XB31alpha, PIK3CD, SAlc-alpha, XB31alpha.

Background: Members of the calsyntenin protein family are localized to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-1, also known as CSTN1, PIK3CD, Alzheimer-related cadherin-like protein, non-classical cadherin XB31alpha, KIAA0911, ALC-ALPHA, alcalpha1, alcalpha2 or FLJ32258, is a 981 amino acid single-pass type I membrane protein that localizes to the membrane of endoplasmic reticulum, Golgi apparatus, cell projections and postsynaptic cells. Expressed in brain, calsyntenin-1 is also found at lower levels in placenta, skeletal muscle, heart and kidney. Calsyntenin-1 binds synaptic Ca2+ with its cytoplasmic domain and plays a role in extracellular proteolysis. Calsyntenin-1 is also known to form a complex with X11 Beta and APP to suppress the metabolic cleavage of APP, and docks vesicular cargo to KLC1. Calsyntenin-1 may be related to the development or progression of Alzheimer?s disease, and two calsyntenin-1 isoforms are produced as a result of alternative splicing events.