Presenilin 1 anticorps (AA 321-430) (AbBy Fluor® 647)

N° du produit ABIN1392708

Cet anticorps anti-Presenilin 1 est un anticorps Lapin Polyclonal détectant Presenilin 1 dans WB, IF (cc) et IF (p). Adapté pour Souris et Rat.

Aperçu rapide pour Presenilin 1 anticorps (AA 321-430) (AbBy Fluor® 647) (ABIN1392708)

Antigène: Presenilin 1 (PSEN1)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 1 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Presenilin 1 anticorps (AbBy Fluor® 647)

Épitope: AA 321-430

Réactivité croisée: Souris, Rat

Homologie: Human,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Presenilin-1/ Presenilin-2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Presenilin 1

Antigène: Presenilin 1 (PSEN1)

Autre désignation: Presenilin 1

Sujet:

Synonyms: AD 3, AD4, AD5, Alzheimer disease 3, Alzheimer disease 4, FAD, Presenilin 1, Presenilin 2, Presenilin-1, Presenilin-2, Presenilin1, Presenilin1, PS1, PS2, PS-1, PS-2, PSEN1, PSEN2, STM2, PSN1_HUMAN, PSN2_HUMAN.

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.

Pathways: Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport