NOS1AP anticorps (AA 128-170) (Alexa Fluor 350)

N° du produit ABIN1394493

Détail du produit anti-NOS1AP anticorps (Alexa Fluor 350)

Antigène: NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))

Épitope: AA 128-170

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOS1AP est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CAPON

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NOS1AP

Antigène: NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))

Autre désignation: CAPON (NOS1AP Produits)

Synonymes: anticorps MGC78853, anticorps Capon, anticorps MGC145362, anticorps 6330408P19Rik, anticorps CAPON, anticorps nitric oxide synthase 1 adaptor protein, anticorps nitric oxide synthase 1 adaptor protein L homeolog, anticorps nitric oxide synthase 1 (neuronal) adaptor protein a, anticorps carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, anticorps chromosome 18 C1orf226 homolog, anticorps nitric oxide synthase 1 (neuronal) adaptor protein, anticorps NOS1AP, anticorps nos1ap.L, anticorps nos1apa, anticorps LOC609484, anticorps nos1ap, anticorps LOC100058633, anticorps C18H1orf226, anticorps Nos1ap

Sujet:

Synonyms: NOS1AP, C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON, C terminal PDZ domain ligand of neuronal nitric oxide synthase, C terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, CAPON, CAPON_HUMAN, Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain, MGC138500, Nitric oxide synthase 1 neuronal adaptor protein, Nitric oxide synthase 1 adaptor protein.

Background: CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.