CLEC11A anticorps (Biotin)

N° du produit ABIN1405339

Détail du produit anti-CLEC11A anticorps (Biotin)

Antigène: CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLEC11A est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Pleckstrin/p47

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CLEC11A

Antigène: CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))

Autre désignation: p47 (CLEC11A Produits)

Synonymes: anticorps CLEC11A, anticorps CLECSF3, anticorps LSLCL, anticorps P47, anticorps SCGF, anticorps AW457320, anticorps Clecsf3, anticorps Scgf, anticorps C-type lectin domain containing 11A, anticorps C-type lectin domain family 11, member a, anticorps CLEC11A, anticorps Clec11a

Sujet:

Synonyms: p47, Platelet 47 kDa protein, Platelet and leukocyte C kinase substrate, Platelet P47, Platelet p47 protein, Pleckstrin, PLEK, PLEK_HUMAN, FLJ27168, OTTHUMP00000159962.

Background: Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89 % sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.

ID gène: 5341