TAB2 anticorps (C-Term)
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- Antigène Voir toutes TAB2 Anticorps
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAB2 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- 14 amino acid synthetic peptide near the carboxy terminus of Human TAB2
- Isotype
- IgG
- Top Product
- Discover our top product TAB2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
- Autre désignation
- TAB2 / MAP3K7IP2 (TAB2 Produits)
- Synonymes
- anticorps CHTD2, anticorps MAP3K7IP2, anticorps 1110030N06Rik, anticorps A530078N03Rik, anticorps Map3k7ip2, anticorps mKIAA0733, anticorps map3k7ip2, anticorps zgc:77446, anticorps TGF-beta activated kinase 1/MAP3K7 binding protein 2, anticorps TAB2, anticorps Tab2, anticorps tab2
- Sujet
- TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.Synonyms: Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, Tab-2
- ID gène
- 23118
- NCBI Accession
- NP_055908
- Pathways
- TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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