Pellino 1 anticorps (C-Term)
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- Antigène Voir toutes Pellino 1 (PELI1) Anticorps
- Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Pellino 1 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- A 15 amino acid peptide near the carboxy terminus of Human Pellino 1
- Isotype
- IgG
- Top Product
- Discover our top product PELI1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))
- Autre désignation
- PELI1 (PELI1 Produits)
- Synonymes
- anticorps 2810468L03Rik, anticorps A930031K15Rik, anticorps AA409794, anticorps AI586297, anticorps D11Ertd676e, anticorps peli1, anticorps peli1.L, anticorps pellino1, anticorps xpellino1, anticorps wu:fd12d01, anticorps zgc:153297, anticorps pellino E3 ubiquitin protein ligase 1, anticorps pellino 1, anticorps pellino E3 ubiquitin protein ligase 1 S homeolog, anticorps pellino E3 ubiquitin protein ligase 1b, anticorps PELI1, anticorps Peli1, anticorps peli1.S, anticorps peli1b
- Sujet
- The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-kB. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.Synonyms: PRISM, Pellino 1, Pellino-1, Pellino-related intracellular-signaling molecule, Protein pellino homolog 1
- Poids moléculaire
- 46 kDa
- ID gène
- 57162
- NCBI Accession
- NP_065702
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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