MYD88 anticorps (AA 171-220)

N° du produit ABIN1453590

Cité dans 1 publication. Cet anticorps anti-MYD88 Polyclonal Lapin (ABIN1453590) détecte spécifiquement MYD88 dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat et Porc.

Aperçu rapide pour MYD88 anticorps (AA 171-220) (ABIN1453590)

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYD88 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-MYD88 anticorps

Épitope: AA 171-220

Fonction: MyD88 Antibody

Specificité: MyD88 Polyclonal Antibody detects endogenous levels of MyD88 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human MyD88. AA range:171-220

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunocytochemistry: 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Références pour anticorps anti-MYD88 (ABIN1453590)

Valerio, Minderman, Mace, Awad: "β-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages." dans: Cellular immunology, Vol. 285, Issue 1-2, pp. 76-83, (2014) (PubMed).

Détails sur MYD88

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Autre désignation: MyD88

Sujet:

Synonyms: MYD88, Myeloid differentiation primary response protein MyD88

Background: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

Gene Name: MyD88

Protein Name: Myeloid differentiation primary response protein MyD88

Poids moléculaire: 33 kDa

ID gène: 4615

OMIM: 602170

UniProt: Q99836

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades