Ret Proto-Oncogene anticorps (pTyr1015)

N° du produit ABIN1531387

L’anticorps anti-Ret Proto-Oncogene Polyclonal Lapin est utilisé pour la détection de Ret Proto-Oncogene dans des échantillons de Humain, Souris, Rat et Singe. Il a été validé pour WB et IHC.

Aperçu rapide pour Ret Proto-Oncogene anticorps (pTyr1015) (ABIN1531387)

Antigène: Ret Proto-Oncogene (RET)

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ret Proto-Oncogene est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Ret Proto-Oncogene anticorps

Épitope: AA 991-1040, pTyr1015

Fonction: Ret (phospho Tyr1015) Antibody

Specificité: Phospho-Ret (Y1015) Polyclonal Antibody detects endogenous levels of Ret protein only when phosphorylated at Y1015.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human Ret around the phosphorylation site of Tyr1015. AA range:991-1040

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Ret Proto-Oncogene

Antigène: Ret Proto-Oncogene (RET)

Autre désignation: Ret

Sujet:

Synonyms: RET, CDHF12, CDHR16, PTC, RET51, Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret

Background: ret proto-oncogene(RET) Homo sapiens This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008],

Gene Name: RET

Protein Name: Proto-oncogene tyrosine-protein kinase receptor Ret

Poids moléculaire: 124 kDa

ID gène: 5979

OMIM: 114500

UniProt: P07949

Pathways: Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation