RECQL2 anticorps (pSer1141)

N° du produit ABIN1531762

Cet anticorps Lapin Polyclonal détecte spécifiquement RECQL2 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour RECQL2 anticorps (pSer1141) (ABIN1531762)

Antigène: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RECQL2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RECQL2 anticorps

Épitope: AA 1107-1156, pSer1141

Fonction: WRN (phospho Ser1141) Antibody

Specificité: Phospho-WRN (S1141) Polyclonal Antibody detects endogenous levels of WRN protein only when phosphorylated at S1141.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141. AA range:1107-1156

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur RECQL2

Antigène: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Autre désignation: Werner Syndrome Helicase

Sujet:

Synonyms: WRN; RECQ3; RECQL2; Werner syndrome ATP-dependent helicase; DNA helicase; RecQ-like type 3; RecQ3; Exonuclease WRN; RecQ protein-like 2

Background: Werner syndrome RecQ like helicase(WRN) Homo sapiens This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008],

Gene Name: WRN

Protein Name: Werner syndrome ATP-dependent helicase

Poids moléculaire: 162 kDa

ID gène: 7486

OMIM: 114500

UniProt: Q14191

Pathways: Réparation de l'ADN