CSNK1A1 anticorps (pTyr294)

N° du produit ABIN1532040

Cet anticorps Lapin Polyclonal détecte spécifiquement CSNK1A1 dans WB, IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour CSNK1A1 anticorps (pTyr294) (ABIN1532040)

Antigène: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSNK1A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-CSNK1A1 anticorps

Épitope: AA 260-309, pTyr294

Fonction: Casein Kinase Iα (phospho Tyr294) Antibody

Specificité: Phospho-Casein Kinase Iα (Y294) Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Y294.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human CK-1 alpha around the phosphorylation site of Tyr294. AA range:260-309

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur CSNK1A1

Antigène: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Autre désignation: CK-1 alpha

Sujet:

Synonyms: CSNK1A1, Casein kinase I isoform alpha, CKI-alpha, CK1, CSNK1A1L, Casein kinase I isoform alpha-like, CKI-alpha-like, CK1

Background: CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2. asein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed: 11955436, PubMed: 1409656, PubMed: 18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed: 23902688). asein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Gene Name: CSNK1A1

Protein Name: Casein kinase I isoform alpha

Poids moléculaire: 38 kDa

ID gène: 1452, 122011

OMIM: 600505

UniProt: P48729

Pathways: Signalisation WNT, Signalisation Hedgehog