Lamin A/C anticorps (pSer22)

N° du produit ABIN1532183

Cet anticorps Lapin Polyclonal détecte spécifiquement Lamin A/C dans WB, IHC, IF et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat. Il a été cité dans 3+ publications.

Aperçu rapide pour Lamin A/C anticorps (pSer22) (ABIN1532183)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Détail du produit anti-Lamin A/C anticorps

Épitope: AA 2-51, pSer22

Fonction: Lamin A/C (phospho Ser22) Antibody

Specificité: Phospho-Lamin A/C (S22) Polyclonal Antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at S22.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human Lamin A around the phosphorylation site of Ser22. AA range:2-51

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Références pour anticorps anti-Lamin A/C (ABIN1532183)

Häge, Sonntag, Svrlanska, Borst, Stilp, Horsch, Müller, Kropff, Milbradt, Stamminger, Schlötzer-Schrehardt, Marschall: "Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation." dans: Viruses, Vol. 13, Issue 2, (2021) (PubMed).

Schütz, Steingruber, Socher, Müller, Wagner, Kögel, Sticht, Marschall: "Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97." dans: Viruses, Vol. 13, Issue 7, (2021) (PubMed).

Häge, Büscher, Pakulska, Hahn, Adrait, Krauter, Borst, Schlötzer-Schrehardt, Couté, Plachter, Marschall: "The Complex Regulatory Role of Cytomegalovirus Nuclear Egress Protein pUL50 in the Production of Infectious Virus." dans: Cells, Vol. 10, Issue 11, (2021) (PubMed).

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: Lamin A

Sujet:

Synonyms: LMNA, LMN1, Prelamin-A/C

Background: lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012],

Gene Name: LMNA

Protein Name: Prelamin-A/C

Poids moléculaire: 74 kDa

ID gène: 4000

OMIM: 115200

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus