ENC1 anticorps (C-Term)

N° du produit ABIN1537267

Détail du produit anti-ENC1 anticorps

Antigène: ENC1 (Ectodermal-Neural Cortex 1 (With BTB-Like Domain) (ENC1))

Épitope: AA 395-423, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ENC1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ENC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-423 amino acids from the C-terminal region of human ENC1.

Clone: RB37065

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: ENC1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur ENC1

Antigène: ENC1 (Ectodermal-Neural Cortex 1 (With BTB-Like Domain) (ENC1))

Autre désignation: ENC1 (ENC1 Produits)

Synonymes: anticorps ENC1, anticorps LOC559101, anticorps CCL28, anticorps ENC-1, anticorps KLHL35, anticorps KLHL37, anticorps NRPB, anticorps PIG10, anticorps TP53I10, anticorps Xencr-3, anticorps enc-1, anticorps encr-3, anticorps Nrpb, anticorps ectodermal-neural cortex 1, anticorps ectodermal-neural cortex 1 (with BTB domain) L homeolog, anticorps ENC1, anticorps enc1, anticorps enc1.L, anticorps Enc1

Sujet: DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53, MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50 % of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.

Poids moléculaire: 66130

ID gène: 8507

NCBI Accession: NP_001243503, NP_001243504, NP_001243505, NP_003624

UniProt: O14682