This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This COL4A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 830-859 amino acids from the Central region of human COL4A6.
anticorps CXDELq22.3, anticorps DELXq22.3, anticorps BB116301, anticorps collagen type IV alpha 6 chain, anticorps collagen, type IV, alpha 6, anticorps COL4A6, anticorps Col4a6, anticorps col4a6
Sujet
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.