VEGFA anticorps (Isoform 165)

N° du produit ABIN155175

Cet anticorps anti-VEGFA Monoclonal Souris (Clone 7G7) (ABIN155175) détecte spécifiquement VEGFA dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour VEGFA anticorps (Isoform 165) (ABIN155175)

Antigène: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp VEGFA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 7G7

Détail du produit anti-VEGFA anticorps

Épitope: Isoform 165

Specificité: The antibody recognizes human VEGF-A. Other species not tested.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogène: Recombinant Human VEGF165 protein (45 kDa)

Isotype: IgG1

Information d'application

Indications d'application: ELISA: Use at 1-15 μg/mL. Western blot: Use at 1-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in sterile water to a concentration of 1.0 mg/mL.

Buffer: PBS, pH 7.4 without preservative or stabilizer.

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: The lyophilized antibody, thought stable at room temperature, is best stored desiccated below 0 °C. Reconstituted anti-VEGF-A is stable at 4 °C for six weeks or can be stored in working aliquots at - 20 °C for longer.

Détails sur VEGFA

Antigène: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Autre désignation: VEGF-A

Sujet: VEGFA is a member of the PDGF/VEGF growth factor family and is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternate transcriptional splice variants, encoding either freely secreted or cell associated isoforms, have been characterized. There is also evidence for the use of non AUG (CUG) translation initiation sites upstream of, and in frame with the first AUG, leading to additional isoforms.Synonyms: VEGF, VEGFA, VPF, Vascular endothelial growth factor A, Vascular permeability factor

ID gène: 7422

NCBI Accession: NP_001020537

UniProt: P15692

Pathways: Signalisation RTK, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling