beta-2 Microglobulin anticorps (Biotin)

N° du produit ABIN1607723

Détail du produit anti-beta-2 Microglobulin anticorps (Biotin)

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta-2 Microglobulin est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): Cross reactivity against b2-Microglobulin from other sources may occur but has not been specifically determined.

Pureté: Anti-beta-2-Microglobulin antibody is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.  Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Biotin, anti-Rabbit Serum as well as purified and partially purified b2-Microglobulin [Human Urine].

niveau d'endotoxine: Low Endotoxin : No

Immunogène: Anti-Beta-2-Microglobulin Antibody was produced by repeated immunizations with beta-2-Microglobulin protein isolated from human urine.
Immunogen Type: Native Protein

Isotype: IgG

Information d'application

Indications d'application: Anti-beta-2-Microglobulin antibody is suitable for western blotting to detect a single band of the expected apparent molecular weight and for ELISA. Researchers should determine optimal titers for applications that are not stated below.
ELISA Dilution: 1:2.000 - 1:10.000
Immunohistochemistry Dilution: 1:500 - 1:3.000
Western Blot Dilution: 1:1.000 - 1:5.000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free

Conseil sur la manipulation: Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store vial at -20 °C or below prior to opening. This vial contains a relatively low volume of reagent (25 µL). To minimize loss of volume dilute 1:10 by adding 225 µL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below.

Date de péremption: Expiration date is one (1) year from date of opening.

Références pour anticorps anti-beta-2 Microglobulin (Biotin) (ABIN1607723)

Keefe, Hwang, Huan, Mendelson, Yao, Courchesne, Saleh, Madhur, Levy: "Evidence for a Causal Role of the SH2B3-β2M Axis in Blood Pressure Regulation." dans: Hypertension (Dallas, Tex. : 1979), Vol. 73, Issue 2, pp. 497-503, (2019) (PubMed).

Détails sur beta-2 Microglobulin

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: Beta-2-Microglobulin (B2M Produits)

Synonymes: anticorps Ly-m11, anticorps beta2-m, anticorps beta2m, anticorps bwm, anticorps wu:fa94c05, anticorps wu:fb10a09, anticorps b2m-W01, anticorps b2m-W03, anticorps b2m-Z01, anticorps b2m-Z02, anticorps b2m-Z03, anticorps B2M, anticorps b2m, anticorps B2MG, anticorps wu:fb66f11, anticorps wu:fj01f08, anticorps zgc:64161, anticorps b-2-m, anticorps beta-2-microglobulin, anticorps beta-2 microglobulin, anticorps beta-2-microglobulin S homeolog, anticorps beta-2-microglobulin, like, anticorps B2M, anticorps B2m, anticorps b2m, anticorps b2m.S, anticorps b2ml

Sujet: Anti-beta-2-Microglobulin Antibody detects beta-2-Microglobulin. Beta-2-microglobulin is a component of the class I major histocompatibility complex (MHC), which are present on all nucleated cells (excludes red blood cells). It is involved in the presentation of peptide antigens to the immune system. Beta-2-microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Anti-beta-2-Microglobulin Antibody is ideal for investigators involved in Cell Signaling, Immunology and Cell Biology research. Synonyms: B2M antibody, Beta 2 microglobulin precursor antibody, Beta chain of mhc class 1 proteins antibody, Hdcma22p antibody

ID gène: 567

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process