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TP53BP1 anticorps

TP53BP1 Reactivité: Humain WB, IHC, IF Hôte: Lapin Monoclonal unconjugated
N° du produit ABIN1679832
  • Antigène Voir toutes TP53BP1 Anticorps
    TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
    Reactivité
    • 94
    • 50
    • 47
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 96
    • 10
    • 2
    • 1
    Lapin
    Clonalité
    • 89
    • 20
    Monoclonal
    Conjugué
    • 60
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp TP53BP1 est non-conjugé
    Application
    • 45
    • 28
    • 27
    • 27
    • 26
    • 19
    • 19
    • 14
    • 11
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Souris
    Attributs du produit
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    A synthesized peptide derived from human 53BP1
    Isotype
    IgG
    Top Product
    Discover our top product TP53BP1 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
    Autre désignation
    TP53BP1 (TP53BP1 Produits)
    Synonymes
    anticorps TP53BP1, anticorps MGC160112, anticorps 53BP1, anticorps Tp53bp1, anticorps m53BP1, anticorps p202, anticorps Trp53bp1, anticorps tumor protein p53 binding protein 1, anticorps tumor suppressor p53-binding protein 1, anticorps tumor protein p53 binding protein 1 (predicted), 5 prime, anticorps transformation related protein 53 binding protein 1, anticorps TP53BP1, anticorps tp53bp1, anticorps LOC100550605, anticorps Trp53bp1, anticorps Tp53bp1
    Sujet
    Double-strand break (DSB repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub and histone H4 dimethylated at 'Lys-20' (H4K20me2, two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast, it is not required for classic NHEJ and V(DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.,53BP1, TDRD30, TP53, p202, p53BP1,Cancer,DNA Damage & Repair,Epigenetics & Nuclear Signaling,Protein phosphorylation,Tumor suppressors,Tumor suppressors_p53 pathway,TP53BP1
    Poids moléculaire
    450 kDa
    ID gène
    7158
    UniProt
    Q12888
    Pathways
    Réparation de l'ADN
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