FGFR3 anticorps (AA 39-138)

N° du produit ABIN1679839

Cet anticorps Lapin Polyclonal détecte spécifiquement FGFR3 dans WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour FGFR3 anticorps (AA 39-138) (ABIN1679839)

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-FGFR3 anticorps

Épitope: AA 39-138

Séquence: PGPEPGQQEQ LVFGSGDAVE LSCPPPGGGP MGPTVWVKDG TGLVPSERVL VGPQRLQVLN ASHEDSGAYS CRQRLTQRVL CHFSVRVTDA PSSGDDEDGE

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 39-138 of human FGFR3 (NP_000133.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FGFR3

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Autre désignation: FGFR3

Sujet: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.,ACH,CD333,CEK2,HSFGFR3EX,JTK4,FGFR3,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,ESC Pluripotency and Differentiation,Immunology & Inflammation,CD markers,Stem Cells,Neural Stem Cells,Cardiovascular,Angiogenesis,FGFR3

Poids moléculaire: 75 kDa/85 kDa/87 kDa/88 kDa

ID gène: 2261

UniProt: P22607

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding