MED23 anticorps (AA 401-500) (Biotin)

N° du produit ABIN1700159

L’anticorps Lapin Polyclonal anti-MED23 a été validé pour ELISA, WB, IHC (p) et IHC (fro). Il convient pour détecter MED23 dans des échantillons de Humain.

Aperçu rapide pour MED23 anticorps (AA 401-500) (Biotin) (ABIN1700159)

Antigène: MED23 (Mediator Complex Subunit 23 (MED23))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED23 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MED23 anticorps (Biotin)

Épitope: AA 401-500

Homologie: Human,Mouse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DRIP130/CRSP130

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MED23

Antigène: MED23 (Mediator Complex Subunit 23 (MED23))

Autre désignation: DRIP130/CRSP130

Sujet:

Synonyms: 130 kDa transcriptional co activator, 133 kDa transcriptional co activator, Activator recruited cofactor 130 kDa component, Activator-recruited cofactor 130 kDa component, ARC 130, ARC130, Cofactor required for Sp1 transcriptional activation subunit 3 130 kDa, Cofactor required for Sp1 transcriptional activation subunit 3 130 kDa mediator, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP 130, CRSP 130 kD subunit, CRSP 133, CRSP 3, CRSP complex subunit 3, CRSP130, CRSP133, CRSP3, CRSP3 protein, DKFZp434H0117, DRIP 130, DRIP130, hSur-2, KIAA1216, MED 23, MED23, MED23_HUMAN, Mediator complex subunit 23, Mediator of RNA polymerase II transcription subunit 23, Protein sur-2 homolog, SUR 2, SUR2, Transcriptional co activator CRSP 130, Transcriptional co activator CRSP130, Transcriptional coactivator CRSP130, Vitamin D3 receptor interacting protein, Vitamin D3 receptor interacting protein complex 130 kDa component, Vitamin D3 receptor-interacting protein complex 130 kDa component.

Background: In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include CRSP (for cofactor required for Sp1 activation), which is required, in conjunction with TAFIIs, for transcriptional activation by Sp1 (2). CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits (3). Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS (4). CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins (2,5). CRSP subunits also associate with larger multimeric coactivaor complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription (6,7).

ID gène: 9439

Pathways: Regulation of Lipid Metabolism by PPARalpha