SARS-CoV NSP3 anticorps (AA 761-860) (Biotin)

N° du produit ABIN1700372

Détail du produit anti-SARS-CoV NSP3 anticorps (Biotin)

Antigène: SARS-CoV NSP3 (SARS-Coronavirus Nonstructural Protein 3 (SARS-CoV NSP3))

Épitope: AA 761-860

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARS-CoV NSP3 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA

Homologie: Human,Mouse,Rat,Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NSP3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SARS-CoV NSP3

Antigène: SARS-CoV NSP3 (SARS-Coronavirus Nonstructural Protein 3 (SARS-CoV NSP3))

Autre désignation: NSP3 (SARS-CoV NSP3 Produits)

Classe de substances: Viral Protein

Sujet:

Synonyms: Cas/HEF1 associated signal transducer, CHAT, FLJ39664, Novel SH2 containing protein 3, Novel SH2-containing protein 3, NSP 3, PRO34088, SH2 domain containing 3C, SH2 domain containing Eph receptor binding protein 1, SH2 domain containing protein 3C, SH2 domain-containing protein 3C, SH2D3_HUMAN, SH2D3C, Shep1.

Background: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).