Spartan anticorps (AA 31-130) (Cy5)

N° du produit ABIN1704795

Détail du produit anti-Spartan anticorps (Cy5)

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Épitope: AA 31-130

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spartan est conjugé à/à la Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C1orf124

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Spartan

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Autre désignation: C1orf124 (C1orf124 Produits)

Synonymes: anticorps Spartan, anticorps c1orf124, anticorps C1orf124, anticorps DDDL1880, anticorps DVC1, anticorps PRO4323, anticorps dJ876B10.3, anticorps C28H1orf124, anticorps SprT-like N-terminal domain, anticorps sprtn, anticorps SPRTN

Sujet:

Synonyms: C1orf124, CA124_HUMAN, Chromosome 1 open reading frame 124, DDDL1880, dJ876B10.3, PRO4323, RP5-876B10.3, Zinc finger RAD18 domain-containing protein C1orf124, SPRTN, SprT-like domain-containing protein Spartan, DVC1, DNA damage protein targeting VCP.

Background: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

ID gène: 83932

UniProt: Q9H040