UCMA anticorps (AA 21-120) (HRP)

N° du produit ABIN1711440

Détail du produit anti-UCMA anticorps (HRP)

Antigène: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Épitope: AA 21-120

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UCMA est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human UCMA

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur UCMA

Antigène: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Autre désignation: UCMA (UCMA Produits)

Synonymes: anticorps BN, anticorps GRP-10, anticorps preproGRP, anticorps proGRP, anticorps grp, anticorps GRP2, anticorps ucma, anticorps zgc:162317, anticorps C10orf49, anticorps GRP, anticorps RGD1308977, anticorps 1110017I16Rik, anticorps AW121955, anticorps Grp, anticorps GRP1, anticorps zgc:85838, anticorps gastrin releasing peptide, anticorps upper zone of growth plate and cartilage matrix associated, anticorps upper zone of growth plate and cartilage matrix associated L homeolog, anticorps upper zone of growth plate and cartilage matrix associated a, anticorps upper zone of growth plate and cartilage matrix associated b, anticorps GRP, anticorps UCMA, anticorps ucma.L, anticorps ucmaa, anticorps ucma, anticorps Ucma, anticorps ucmab

Sujet:

Synonyms: C10orf49, Gla rich protein, Gla-rich protein, Grp, GRP, OTTMUSP00000011599, RP23-272I15.1, UCMA, Ucma-C, UCMA_HUMAN, Unique cartilage matrix associated protein, Unique cartilage matrix-associated protein C-terminal fragment, Upper zone of growth plate and cartilage matrix associated.

Background: UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.

ID gène: 221044