LAMTOR2 anticorps (AA 3-100) (HRP)

N° du produit ABIN1712086

Détail du produit anti-LAMTOR2 anticorps (HRP)

Antigène: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Épitope: AA 3-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMTOR2 est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ROBLD3

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur LAMTOR2

Antigène: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Autre désignation: ROBLD3 (LAMTOR2 Produits)

Synonymes: anticorps ENDAP, anticorps HSPC003, anticorps MAPBPIP, anticorps MAPKSP1AP, anticorps ROBLD3, anticorps Ragulator2, anticorps p14, anticorps 2010111E04Rik, anticorps AL022628, anticorps Mapbpip, anticorps P14, anticorps Rab25, anticorps Robld3, anticorps RGD1562501, anticorps cg5189, anticorps endap, anticorps hspc003, anticorps mapbpip, anticorps mapbpip-B, anticorps mapksp1ap, anticorps ragulator2, anticorps robld3, anticorps robld3-b, anticorps zgc:100811, anticorps lamtor2, anticorps lamtor2-a, anticorps lamtor2-b, anticorps mapbpip-A, anticorps robld3-a, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog, anticorps LAMTOR2, anticorps Lamtor2, anticorps lamtor2.S, anticorps lamtor2, anticorps lamtor2.L

Sujet:

Synonyms: ENDAP, Endosomal adaptor protein p14, HSPC003, LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Late endosomal/lysosomal Mp1 interacting protein, Late endosomal/lysosomal Mp1-interacting protein, LTOR2_HUMAN, MAPBPIP, MAPKSP1 adaptor protein, MAPKSP1AP, Mitogen activated protein binding protein interacting protein, Mitogen-activated protein-binding protein-interacting protein, p14, Ragulator complex protein LAMTOR2, Ragulator2, Roadblock domain containing 3, Roadblock domain containing protein 3, Roadblock domain-containing protein 3, ROBLD 3, RP11 336K24.9.

Background: MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. MAPBPIP (mitogen-activated protein-binding protein-interacting protein), also known as p14 and late endosomal/lysosomal MP1-interacting protein, functions as an adaptor protein augmenting the regulation of the MAP kinase cascade. Partner proteins MAPBPIP and MP1 are structurally almost identical each with a five-stranded -sheet flanked between a two-helix and one-helix layer. MAPBPIP compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. Knockdown of the individual proteins in the MP1/MAPBPIP complex resulted in decreased expression of the partner proteins which implies greater stability of the heterodimeric complex than either MP1 or MAPBPIP individually. Early research suggests the MP1-MAPBPIP-MEK-1 signaling complex may be critical in the regulation of tissue homeostasis.

Pathways: Signalisation PI3K-Akt