HUWE1 anticorps (AA 3201-3400) (HRP)

N° du produit ABIN1712174

Détail du produit anti-HUWE1 anticorps (HRP)

Antigène: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Épitope: AA 3201-3400

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUWE1 est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ARF6

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HUWE1

Antigène: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Autre désignation: ARFBP1 (HUWE1 Produits)

Synonymes: anticorps ARF-BP1, anticorps HECTH9, anticorps HSPC272, anticorps Ib772, anticorps LASU1, anticorps MULE, anticorps URE-B1, anticorps UREB1, anticorps 5430439H10Rik, anticorps AU041296, anticorps Arf-bp1, anticorps C430014N20Rik, anticorps C80292, anticorps Gm1718, anticorps Mule, anticorps Ureb1, anticorps HUWE1, anticorps si:dkey-242a8.2, anticorps Huwe1, anticorps mule, anticorps ib772, anticorps lasu1, anticorps ureb1, anticorps hecth9, anticorps arf-bp1, anticorps hspc272, anticorps HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, anticorps HECT, UBA and WWE domain containing 1, anticorps E3 ubiquitin-protein ligase HUWE1, anticorps HUWE1, anticorps Huwe1, anticorps huwe1, anticorps LOC100123214, anticorps LOC100380641

Sujet:

Synonyms: ARF binding protein 1, ARF BP1, ARF-binding protein 1, ARF-BP1, BJ-HCC-24 tumor antigen, E3 ubiquitin protein ligase HUWE1, E3 ubiquitin-protein ligase HUWE1, HECT, HECT domain protein LASU1, HECT UBA and WWE domain containing protein 1, HectH9, Homologous to E6AP carboxyl terminus homologous protein 9, HUWE, Huwe1, HUWE1_HUMAN, Ib772, KIAA0312, KIAA1578, Large structure of UREB1, LASU1, Mcl 1 ubiquitin ligase E3, Mcl-1 ubiquitin ligase E3, MULE, UBA and WWE domain-containing protein 1, Upstream regulatory element-binding protein 1, URE B1, URE-B1, URE-binding protein 1, UREB 1, UREB1.

Background: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.

ID gène: 382