CRP2BP is a 782 amino acid protein encoded by the human gene CSRP2BP. CRP2BP specifically interacts with the double LIM domain protein CRP2. The LIM domain is a conserved cysteine and histidine-containing structural module of two tandemly arranged zinc fingers. It has been identified in single or multiple copies in a variety of regulatory proteins, either in combination with defined functional domains, like homeodomains, or alone, like in the CRP family of LIM proteins. Members of the cysteine- and glycine-rich protein family (CRP1, CRP2 and CRP3) contain two zinc-binding LIM domains, LIM1 (amino-terminal) and LIM2 (carboxyl-terminal), and are implicated in diverse cellular processes linked to differentiation, growth control and pathogenesis. Although present in cytoplasm, CRP2BP is mainly a ubiquitously expressed nuclear protein, with highest expression in skeletal muscle and heart.
Synonyms: ADA2A containing complex subunit 2, ADA2A-containing complex subunit 2, ATAC2, CRP2 binding partner, CRP2-binding partner, CRP2BP, CSR2B_HUMAN, CSRP2 binding protein, CSRP2-binding protein, Csrp2bp, Cysteine rich protein 2 binding protein, Cysteine-rich protein 2-binding protein.