Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
Synonyms: DNA helicase V, far upstream element FUSE binding protein 1, Far upstream element FUSE binding protein 4, Far upstream element binding protein 1, far upstream element binding protein, Far upstream element-binding protein 1, FBP, FUBP, Fubp1, FUBP1_HUMAN, Fubp4, FUSE binding protein 1, FUSE-binding protein 1, HDH V.