EPOR anticorps

N° du produit ABIN1720915

Cet anticorps Souris Monoclonal détecte spécifiquement EPOR dans FACS et cELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour EPOR anticorps (ABIN1720915)

Antigène: EPOR (Erythropoietin Receptor (EPOR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EPOR est non-conjugé

Application: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Clone: VP-2E8

Détail du produit anti-EPOR anticorps

Specificité: Anti-human Epo-R

Attributs du produit: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding the ECD of human Epo-R

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Commentaires:

Synonyms: Erythropoietin receptor

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Références pour anticorps anti-EPOR (ABIN1720915)

Maxwell, Melendez-Rodríguez, Matchett, Aragones, Ben-Califa, Jaekel, Hengst, Lindner, Bernardini, Brockmeier, Fandrey, Grunert, Oster, Mittelman, El-Tanani, Thiersch, Schneider Gasser, Gassmann et al.: "Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. ..." dans: British journal of haematology, Vol. 168, Issue 3, pp. 429-42, (2015) (PubMed).

Hedley, Allan, Xenocostas: "The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 20, pp. 6373-80, (2011) (PubMed).

Détails sur EPOR

Antigène: EPOR (Erythropoietin Receptor (EPOR))

Autre désignation: EPOR

Sujet: Erythropoietin receptor (Epo-R) belongs to the cytokine receptor family and is a 507 amino acid type I transmembrane protein. EpoR pre-exists as dimers which changes the homodimerized state after binding of its 34 kDa ligand erythropoietin (Epo). Erythropoietin is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. Both, Epo and Epo-R are essential for the production of red blood cells due to Epo exerts its function through the Epo receptor. The Epo-R is also expressed in many organs outside the bone marrow, suggesting that Epo is a pleiotropic anti-apoptotic factor. Signaling pathways have been shown to influence numerous cellular functions in normal and tumor cells, including proliferation, apoptosis, and drug resistance.

UniProt: P19235

Pathways: Signalistation JAK/STAT