ATP2C1 anticorps

N° du produit ABIN1724719

Détail du produit anti-ATP2C1 anticorps

Antigène: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATP2C1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: purified

Immunogène: Purified recombinant fragment of ATP2C1 expressed in E. coli.

Clone: 4G12

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-ATP2C1 (ABIN1724719)

Yokota, Sawamura: "Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." dans: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).

Majore, Biolcati, Barboni, Cannistraci, Binni, Crisi, Picardo, Grammatico: "ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease." dans: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 933-5, (2005) (PubMed).

Détails sur ATP2C1

Antigène: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Autre désignation: ATP2C1 (ATP2C1 Produits)

Synonymes: anticorps ATP2C1, anticorps ATP2C1A, anticorps BCPM, anticorps HHD, anticorps PMR1, anticorps SPCA1, anticorps hSPCA1, anticorps Spca1, anticorps si:dkey-11p23.6, anticorps SPCA, anticorps 1700121J11Rik, anticorps AW061228, anticorps D930003G21Rik, anticorps pmr1, anticorps ATPase secretory pathway Ca2+ transporting 1, anticorps ATPase, Ca++ transporting, type 2C, member 1, anticorps ATPase, Ca++-sequestering, anticorps ATP2C1, anticorps atp2c1, anticorps Atp2c1

Sujet:

Description: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

Aliases: HHD, BCPM, PMR1, SPCA1

Poids moléculaire: 100 kDa

ID gène: 27032

HGNC: 27032

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process