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Integrin Alpha2b anticorps (AA 45-149)

Name: Integrin Alpha2b anticorps (AA 45-149)
Brand: antibodies-online
SKU: ABIN1724823
Price: 644.71 EUR
Availability: InStock

CD41 Reactivité: Humain FACS, WB, ELISA, IHC Hôte: Souris Monoclonal 2E10C9 unconjugated

Flow cytometric analysis of HL60 cells using ITGA2B mouse mAb (green) and negative control (purple). (Integrin Alpha2b anticorps (AA 45-149))

FACS

Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ITGA2B mouse mAb with DAB staining. (Integrin Alpha2b anticorps (AA 45-149))

IHC

Western blot analysis using ITGA2B mAb against human ITGA2B recombinant protein. (Integrin Alpha2b anticorps (AA 45-149))

Western blot analysis using ITGA2B mAb against HEK293 (1) and ITGA2B (AA: 45-149)-hIgGFc transfected HEK293 (2) cell lysate. (Integrin Alpha2b anticorps (AA 45-149))

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (Integrin Alpha2b anticorps (AA 45-149))

ELISA

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ITGA2B mouse mAb with DAB staining. (Integrin Alpha2b anticorps (AA 45-149))

IHC

6 images

(2 références)

N° du produit ABIN1724823

Fiche de données

Antigène Voir toutes Integrin Alpha2b (CD41) Anticorps

Integrin Alpha2b (CD41)
Épitope
16

5

4

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 45-149
Reactivité
125

34

21

5

5

4

3

2

2

2

1

1

1

1

1
Humain
Hôte
84

43

25
Souris
Anticorps secondaires appropriés
Clonalité
106

40

1
Monoclonal
Conjugué
60

17

13

12

6

4

4

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp Integrin Alpha2b est non-conjugé
Application
106

48

33

28

21

19

13

13

11

10

8

5

3

3

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification

purified

Immunogène

Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. coli.

Clone

2E10C9

Isotype

IgG1

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anti-Integrin Alpha2b (CD41) antibody
CD41 Reactivité: Souris FACS, ELISA, IHC (fro), IP, IHC (p) Hôte: Rat Monoclonal MWReg30 unconjugated

anti-Integrin Alpha2b (CD41) antibody
CD41 Reactivité: Humain, Non-Human Primate FACS, IHC (fro) Hôte: Souris Monoclonal HIP2 unconjugated

anti-Integrin Alpha2b (CD41) antibody (Biotin)
CD41 Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-06 Biotin

anti-Integrin Alpha2b (CD41) antibody (FITC)
CD41 Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-06 FITC

anti-Integrin Alpha2b (CD41) (AA 677-711), (C-Term) antibody
CD41 Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated

anti-Integrin Alpha2b (CD41) antibody
CD41 Reactivité: Humain, Non-Human Primate FACS, IHC (fro) Hôte: Souris Monoclonal HIP8 unconjugated

Indications d'application

ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C/-20 °C

Stockage commentaire

4°C, -20°C for long term storage
Park, Chung, Lee, Park, Kim, Kim: "Novel and recurrent mutations of ITGA2B and ITGB3 genes in Korean patients with Glanzmann thrombasthenia." dans: Pediatric blood & cancer, Vol. 59, Issue 2, pp. 335-8, (2012) (PubMed).

Nurden, Fiore, Nurden, Pillois: "Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models." dans: Blood, Vol. 118, Issue 23, pp. 5996-6005, (2011) (PubMed).
Antigène

Integrin Alpha2b (CD41)

Autre désignation

ITGA2B (CD41 Produits)

Synonymes

anticorps AI172977, anticorps CD41, anticorps CD41B, anticorps GpIIb, anticorps alphaIIb, anticorps BDPLT16, anticorps BDPLT2, anticorps GP2B, anticorps GPIIb, anticorps GT, anticorps GTA, anticorps HPA3, anticorps integrin alpha 2b, anticorps integrin subunit alpha 2b, anticorps Itga2b, anticorps ITGA2B

Sujet

Description: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. ,
Aliases: GT, GTA, CD41, GP2B, HPA3, CD41B, GPIIb, BDPLT2

Poids moléculaire

113.4 kDa

ID gène

3674

HGNC

3674

Pathways

Integrin Complex