APAF1 anticorps (C-Term)

N° du produit ABIN1731833

Détail du produit anti-APAF1 anticorps

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Épitope: AA 1158-1177, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APAF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Reacts with human, mouse, and rat Apaf1 (130 kDa).

Purification: Purified

Immunogène: Synthetic peptide, corresponding to amino acids 1158-1177 (C-terminus) of Human Apaf 1. The sequence of the immunogenic peptide differs from that of murine Apaf1 byone amino acid

Isotype: IgG

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC(10 - 20 μg/mL) WB(1 - 10 μg/mL) ELISA(1:100 - 1:2000)

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Dilute in PBS or medium that is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Date de péremption: 12 months

Détails sur APAF1

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Autre désignation: Apaf1 (APAF1 Produits)

Synonymes: anticorps APAF1, anticorps ARK, anticorps Apaf-1, anticorps Apaf1, anticorps CG6829, anticorps D-Apaf-1, anticorps DARK, anticorps Dapaf-1, anticorps Dapaf-1/HAC-1, anticorps Dark, anticorps Dark/Apaf-I, anticorps Dark/Dapaf-1/HAC1, anticorps Dark/Hac-1/dApaf-1, anticorps Dark/Hac-1/dApaf1, anticorps Dmel\\CG6829, anticorps Hac-1, anticorps Hac-1/Dark, anticorps Hac1, anticorps T1, anticorps anon-53Fa, anticorps apaf-1, anticorps apaf1, anticorps arc, anticorps ark, anticorps dAPAF-1, anticorps dApaf-1, anticorps dApaf-1/DARK/HAC-1, anticorps dApaf1, anticorps dArk, anticorps dapaf, anticorps dapaf-1, anticorps dapaf-1L, anticorps dapaf-1S, anticorps dark, anticorps dark/dapaf-1/hac-1, anticorps dark/hac-1/dapaf-1, anticorps hac-1, anticorps hac1, anticorps l(2)SH0173, anticorps APAF-1, anticorps CED4, anticorps 6230400I06Rik, anticorps Apaf1l, anticorps fog, anticorps mKIAA0413, anticorps zgc:136543, anticorps Death-associated APAF1-related killer, anticorps apoptotic peptidase activating factor 1 L homeolog, anticorps apoptotic peptidase activating factor 1, anticorps Dark, anticorps apaf1.L, anticorps apaf1, anticorps APAF1, anticorps Apaf1

Sujet: The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis proteaseactivating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

Apoptotic protease-activating factor 1, APAF-1 Gene name: APAF1, KIAA0413, CED4

ID gène: 317

UniProt: O14727

Pathways: Signalisation p53, Apoptose, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity