APAF1 anticorps (AA 12-28)

N° du produit ABIN1731834

Cet anticorps anti-APAF1 Polyclonal Lapin (ABIN1731834) détecte spécifiquement APAF1 dans WB, IF, ICC et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour APAF1 anticorps (AA 12-28) (ABIN1731834)

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APAF1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-APAF1 anticorps

Épitope: AA 12-28

Specificité: Reacts with human and mouse Apaf1.

Purification: Purified

Immunogène: Synthetic peptide, corresponding to amino acids 12-28 of Human Apaf 1. The sequence of the immunogenic peptide differs from that of murine Apaf1 by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC(1 - 2 μg/mL) IF (10 μg/mL) WB(1 - 2 μg/mL)

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Dilute in PBS or medium that is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Date de péremption: 12 months

Détails sur APAF1

Antigène: APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))

Autre désignation: Apaf1

Sujet: The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis proteaseactivating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

Apoptotic protease-activating factor 1, APAF-1 Gene name: APAF1, KIAA0413, CED4

ID gène: 317

UniProt: O14727

Pathways: Signalisation p53, Apoptose, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity