C5AR1 anticorps (AA 15-27)

N° du produit ABIN1774738

Cet anticorps Souris Monoclonal détecte spécifiquement C5AR1 dans WB, FACS, IHC (p) et IP. Il présente une réactivité envers Humain, Boeuf (Vache), Lapin et Furet et a été mentionné dans 3+ publications.

Aperçu rapide pour C5AR1 anticorps (AA 15-27) (ABIN1774738)

Antigène: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Reactivité: Humain, Boeuf (Vache), Lapin, Furet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C5AR1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Clone: S5-1

Détail du produit anti-C5AR1 anticorps

Épitope: AA 15-27

Fonction: Anti-Hu CD88 Purified

Specificité: The mouse monoclonal antibody S5/1 recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.

Réactivité croisée (Details): Human, Bovine, Ferret, Rabbit

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR

Isotype: IgG2a kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 3-12 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-C5AR1 (ABIN1774738)

Conway Morris, Kefala, Wilkinson, Dhaliwal, Farrell, Walsh, Mackenzie, Reid, Davidson, Haslett, Rossi, Sallenave, Simpson: "C5a mediates peripheral blood neutrophil dysfunction in critically ill patients." dans: American journal of respiratory and critical care medicine, Vol. 180, Issue 1, pp. 19-28, (2009) (PubMed).

Cain, Monk: "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)." dans: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7165-9, (2002) (PubMed).

Kiener, Baghestanian, Dominkus, Walchshofer, Ghannadan, Willheim, Sillaber, Graninger, Smolen, Valent: "Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis." dans: Arthritis and rheumatism, Vol. 41, Issue 2, pp. 233-45, (1998) (PubMed).

Détails sur C5AR1

Antigène: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Autre désignation: CD88

Sujet: Complement C5a receptor 1,CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.,C5A, C5R1, C5AR1

ID gène: 728

UniProt: P21730

Pathways: Système du Complément