SOS1 anticorps

N° du produit ABIN1819949

L’anticorps anti-SOS1 Monoclonal Souris est utilisé pour la détection de SOS1 dans des échantillons de Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Singe, Cobaye et Porc. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour SOS1 anticorps (ABIN1819949)

Antigène: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reactivité: Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Singe, Cobaye, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOS1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: SOS-1

Détail du produit anti-SOS1 anticorps

Specificité: Recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.

Purification: Protein A purified

Immunogène: Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Elephant, Panda, Bovine, Cat, Horse, Rabbit, Opossum, Guinea pig (100%), Dog, Turkey, Zebra finch (95%), Lizard (89%).

Type of Immunogen: Synthetic peptide

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, IF, WB (1 μg/mL)

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur SOS1

Antigène: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Autre désignation: SOS1 / HGF

Sujet: Name/Gene ID: SOS1

Synonyms: SOS1, GINGF, NS4, SOS-1, Son of sevenless homolog 1, GF1, GGF1

ID gène: 6654

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling