Caspase 8 anticorps (N-Term)
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- Antigène Voir toutes Caspase 8 (CASP8) Anticorps
- Caspase 8 (CASP8)
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Caspase 8 est non-conjugé
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Application
- Western Blotting (WB)
- Stérilité
- 0.2 μm filtered
- Immunogène
- Recombinant human caspase-8.
- Clone
- FLICE-1
- Isotype
- IgG1
- Top Product
- Discover our top product CASP8 Anticorps primaire
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- Indications d'application
- Western Blot The optimal dilution for a specific application should be determined by the researcher.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Mouse monoclonal antibody against human Caspase-8 (cysteine-requiring aspartate protease-8). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Antibody was purified by 0.2 µm sterile filtration.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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- Antigène
- Caspase 8 (CASP8)
- Autre désignation
- Caspase-8 (CASP8 Produits)
- Synonymes
- anticorps casp8-A, anticorps xCaspase-8, anticorps casp8, anticorps CASP8, anticorps CASP-8, anticorps FLICE, anticorps MACH, anticorps Mch5, anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps MCH5, anticorps caspase-8, anticorps zgc:92075, anticorps caspase 8 L homeolog, anticorps death related ced-3/Nedd2-like protein, anticorps caspase 8, anticorps caspase-8, anticorps caspase-8-like, anticorps caspase 8, apoptosis-related cysteine peptidase, anticorps casp8.L, anticorps LOC661095, anticorps CASP8, anticorps LOC5563818, anticorps casp8, anticorps LOC100222284, anticorps Casp8
- Sujet
- Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes, which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains, which are removed to activate the enzyme along with cleavage in the two subunits. These subunits then form the active protease, which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis.
- Pathways
- Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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