KCNMB2 anticorps (N-Term)

N° du produit ABIN1881476

Détail du produit anti-KCNMB2 anticorps

Antigène: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNMB2 est non-conjugé

Application: Western Blotting (WB)

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KCNMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNMB2.

Clone: RB42799

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-KCNMB2 (ABIN1881476)

Treviño, Yang, French, Hunger, Carroll, Devidas, Willman, Neale, Downing, Raimondi, Pui, Evans, Relling: "Germline genomic variants associated with childhood acute lymphoblastic leukemia." dans: Nature genetics, Vol. 41, Issue 9, pp. 1001-5, (2009) (PubMed).

Lee, Cui: "{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia." dans: The Journal of physiology, Vol. 587, Issue Pt 7, pp. 1481-98, (2009) (PubMed).

Zarei, Song, Wilson, Cox, Colom, Knaus, Stefani, Toro: "Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel." dans: Neuroscience, Vol. 147, Issue 1, pp. 80-9, (2007) (PubMed).

Zeng, Benzinger, Xia, Lingle: "BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 17, pp. 4707-15, (2007) (PubMed).

Orio, Torres, Rojas, Carvacho, Garcia, Toro, Valverde, Latorre: "Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel." dans: The Journal of general physiology, Vol. 127, Issue 2, pp. 191-204, (2006) (PubMed).

Détails sur KCNMB2

Antigène: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Autre désignation: KCNMB2 (KCNMB2 Produits)

Synonymes: anticorps KCNMB3, anticorps zgc:101842, anticorps KCNMB2, anticorps 2700049B16Rik, anticorps 3110031N04Rik, anticorps Kcmb2, anticorps potassium calcium-activated channel subfamily M regulatory beta subunit 2, anticorps potassium large conductance calcium-activated channel, subfamily M, beta member 2, anticorps KCNMB2, anticorps kcnmb2, anticorps Kcnmb2

Sujet: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene. [provided by RefSeq].

Poids moléculaire: 27130

NCBI Accession: NP_001265840, NP_005823, NP_852006

UniProt: Q9Y691