This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This NCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-675 amino acids from the C-terminal region of human NCBP1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Hwang, Sato, Tang, Matsuda, Maquat: "UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps." dans: Molecular cell, Vol. 39, Issue 3, pp. 396-409, (2010) (PubMed).
Kim, Cho, Choi, Kim, Kim, Ko, Jang, Kim: "A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation." dans: Genes & development, Vol. 23, Issue 17, pp. 2033-45, (2009) (PubMed).
Dias, Wilson, Rojas, Ambrosio, Cerione: "The molecular basis for the regulation of the cap-binding complex by the importins." dans: Nature structural & molecular biology, Vol. 16, Issue 9, pp. 930-7, (2009) (PubMed).
Worch, Jankowska-Anyszka, Niedzwiecka, Stepinski, Mazza, Darzynkiewicz, Cusack, Stolarski: "Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex." dans: Journal of molecular biology, Vol. 385, Issue 2, pp. 618-27, (2009) (PubMed).
Ma, Yoon, Richardson, Jülich, Blenis: "SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs." dans: Cell, Vol. 133, Issue 2, pp. 303-13, (2008) (PubMed).
Antigène
NCBP1
(Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
anticorps CBP80, anticorps CG7035, anticorps Dmel\\CG7035, anticorps EG:84H4.3, anticorps ncbp, anticorps sto1, anticorps cbp80, anticorps AU014645, anticorps AW538051, anticorps NCBP, anticorps Sto1, anticorps ncbp1, anticorps ABA HYPERSENSITIVE 1, anticorps ATCBP80, anticorps CAP-BINDING PROTEIN 80, anticorps ENS, anticorps ENSALADA, anticorps NUCLEAR CAP-BINDING PROTEIN CBP80, anticorps T10F5.8, anticorps T10F5_8, anticorps cap binding protein 80, anticorps nuclear cap binding protein subunit 1, anticorps nuclear cap binding protein subunit 1 S homeolog, anticorps nuclear cap binding protein subunit 1, 80kDa, anticorps nuclear cap binding protein subunit 1 L homeolog, anticorps ARM repeat superfamily protein, anticorps Nuclear cap-binding protein subunit 1-A, anticorps Nuclear cap-binding protein subunit 1, anticorps Cbp80, anticorps ncbp1, anticorps ncbp1.S, anticorps NCBP1, anticorps Ncbp1, anticorps ncbp1.L, anticorps ABH1, anticorps nbp1a, anticorps ncbp-1
Sujet
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.