SPIB anticorps (C-Term)

N° du produit ABIN1881823

Détail du produit anti-SPIB anticorps

Antigène: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Épitope: AA 216-245, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPIB est non-conjugé

Application: Western Blotting (WB)

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SPIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the C-terminal region of human SPIB.

Clone: RB40547

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SPIB (ABIN1881823)

Liu, Invernizzi, Lu, Kosoy, Lu, Bianchi, Podda, Xu, Xie, Macciardi, Selmi, Lupoli, Shigeta, Ransom, Lleo, Lee, Mason, Myers, Peltekian, Ghent, Bernuzzi, Zuin, Rosina, Borghesio, Floreani et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." dans: Nature genetics, Vol. 42, Issue 8, pp. 658-60, (2010) (PubMed).

Schmidlin, Diehl, Nagasawa, Scheeren, Schotte, Uittenbogaart, Spits, Blom: "Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression." dans: Blood, Vol. 112, Issue 5, pp. 1804-12, (2008) (PubMed).

Nagasawa, Schmidlin, Hazekamp, Schotte, Blom: "Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B." dans: European journal of immunology, Vol. 38, Issue 9, pp. 2389-400, (2008) (PubMed).

Dontje, Schotte, Cupedo, Nagasawa, Scheeren, Gimeno, Spits, Blom: "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B." dans: Blood, Vol. 107, Issue 6, pp. 2446-52, (2006) (PubMed).

Geng, Vedeckis: "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter." dans: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43264-71, (2005) (PubMed).

Détails sur SPIB

Antigène: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Autre désignation: SPIB (SPIB Produits)

Synonymes: anticorps spi-b, anticorps spib, anticorps spiba, anticorps SPI-B, anticorps B42b-like, anticorps Spi-B, anticorps Spi-B transcription factor L homeolog, anticorps Spi-B transcription factor, anticorps Spi-B transcription factor (Spi-1/PU.1 related), anticorps spib.L, anticorps SPIB, anticorps Spib

Sujet: SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1, MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).

Poids moléculaire: 28819

NCBI Accession: NP_001230927, NP_001230928, NP_001230929, NP_003112

UniProt: Q01892