SQSTM1 anticorps (C-Term)

N° du produit ABIN1881829

Cet anticorps Lapin Polyclonal détecte spécifiquement SQSTM1 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour SQSTM1 anticorps (C-Term) (ABIN1881829)

Antigène: SQSTM1 (Sequestosome 1 (SQSTM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SQSTM1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB41445

Détail du produit anti-SQSTM1 anticorps

Épitope: AA 383-409, C-Term

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SQSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-409 amino acids from the C-terminal region of human SQSTM1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SQSTM1 (ABIN1881829)

Visconti, Langston, Alonso, Goodman, Selby, Fraser, Ralston: "Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 25, Issue 11, pp. 2368-73, (2010) (PubMed).

Ding, Ni, Li, Liao, Chen, Stolz, Dorn, Yin: "Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming." dans: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27879-90, (2010) (PubMed).

Jain, Lamark, Sjøttem, Larsen, Awuh, Øvervatn, McMahon, Hayes, Johansen: "p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription." dans: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22576-91, (2010) (PubMed).

Lau, Wang, Zhao, Villeneuve, Wu, Jiang, Sun, White, Zhang: "A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62." dans: Molecular and cellular biology, Vol. 30, Issue 13, pp. 3275-85, (2010) (PubMed).

Gao, Cao, Bao, Zuo, Xie, Cai, Fu, Zhang, Wu, Zhang, Chen: "Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation." dans: Nature cell biology, Vol. 12, Issue 8, pp. 781-90, (2010) (PubMed).

Détails sur SQSTM1

Antigène: SQSTM1 (Sequestosome 1 (SQSTM1))

Autre désignation: SQSTM1

Sujet: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Poids moléculaire: 47687

NCBI Accession: NP_001135770, NP_001135771, NP_003891

UniProt: Q13501

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy