UGT2B28 anticorps (AA 218-246)

N° du produit ABIN1881976

Détail du produit anti-UGT2B28 anticorps

Antigène: UGT2B28 (UDP Glucuronosyltransferase 2 Family, Polypeptide B28 (UGT2B28))

Épitope: AA 218-246

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UGT2B28 est non-conjugé

Application: Western Blotting (WB)

Homologie: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This UGT2B28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human UGT2B28.

Clone: RB41660

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-UGT2B28 (ABIN1881976)

Setlur, Chen, Hossain, Ha, Van Doren, Stenzel, Steiner, Oldridge, Kitabayashi, Banerjee, Chen, Schäfer, Horninger, Lee, Rubin, Klocker, Demichelis: "Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 229-39, (2010) (PubMed).

Ménard, Eap, Harvey, Guillemette, Lévesque: "Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism." dans: Human mutation, Vol. 30, Issue 9, pp. 1310-9, (2009) (PubMed).

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." dans: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Lévesque, Turgeon, Carrier, Montminy, Beaulieu, Bélanger: "Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase." dans: Biochemistry, Vol. 40, Issue 13, pp. 3869-81, (2001) (PubMed).

Détails sur UGT2B28

Antigène: UGT2B28 (UDP Glucuronosyltransferase 2 Family, Polypeptide B28 (UGT2B28))

Autre désignation: UGT2B28 (UGT2B28 Produits)

Sujet: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Poids moléculaire: 60906

NCBI Accession: NP_001193933, NP_444267

UniProt: Q9BY64

Pathways: Steroid Hormone Biosynthesis