USH1C anticorps (N-Term)

N° du produit ABIN1881984

Détail du produit anti-USH1C anticorps

Antigène: USH1C (Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C))

Épitope: AA 1-30, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USH1C est non-conjugé

Application: Western Blotting (WB)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This USH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USH1C.

Clone: RB41722

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-USH1C (ABIN1881984)

Yan, Pan, Chen, Wu, Zhang: "The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 9, pp. 4040-5, (2010) (PubMed).

Jaijo, Aller, García-García, Aparisi, Bernal, Avila-Fernández, Barragán, Baiget, Ayuso, Antiñolo, Díaz-Llopis, Külm, Beneyto, Nájera, Millán: "Microarray-based mutation analysis of 183 Spanish families with Usher syndrome." dans: Investigative ophthalmology & visual science, Vol. 51, Issue 3, pp. 1311-7, (2010) (PubMed).

Pan, Yan, Wu, Zhang: "Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 14, pp. 5575-80, (2009) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." dans: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Détails sur USH1C

Antigène: USH1C (Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C))

Autre désignation: USH1C (USH1C Produits)

Synonymes: anticorps AIE-75, anticorps DFNB18, anticorps DFNB18A, anticorps NY-CO-37, anticorps NY-CO-38, anticorps PDZ-45, anticorps PDZ-73, anticorps PDZ-73/NY-CO-38, anticorps PDZ73, anticorps PDZD7C, anticorps ush1cpst, anticorps 2010016F01Rik, anticorps harmonin, anticorps zgc:136806, anticorps ush1c, anticorps USH1 protein network component harmonin, anticorps harmonin, anticorps Usher syndrome 1C, anticorps USH1 protein network component harmonin L homeolog, anticorps USH1C, anticorps CpipJ_CPIJ012732, anticorps Ush1c, anticorps ush1c, anticorps ush1c.L

Sujet: This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 62211

NCBI Accession: NP_005700, NP_710142

UniProt: Q9Y6N9

Pathways: Sensory Perception of Sound