XPC anticorps (N-Term)

N° du produit ABIN1882000

Cet anticorps Lapin Polyclonal détecte spécifiquement XPC dans WB. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour XPC anticorps (N-Term) (ABIN1882000)

Antigène: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPC est non-conjugé

Application: Western Blotting (WB)

Clone: RB40964

Détail du produit anti-XPC anticorps

Épitope: AA 154-183, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-XPC (ABIN1882000)

Stern, Lin, Figueroa, Kelsey, Kiltie, Yuan, Matullo, Fletcher, Benhamou, Taylor, Placidi, Zhang, Steineck, Rothman, Kogevinas, Silverman, Malats, Chanock, Wu, Karagas: "Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer." dans: Cancer research, Vol. 69, Issue 17, pp. 6857-64, (2009) (PubMed).

Détails sur XPC

Antigène: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Autre désignation: XPC

Sujet: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 105953

NCBI Accession: NP_001139241, NP_004619

UniProt: Q01831

Pathways: Signalisation p53, Réparation de l'ADN