NEK6 anticorps (N-Term)

N° du produit ABIN1882104

Détail du produit anti-NEK6 anticorps

Antigène: NEK6 (NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6))

Épitope: AA 8-39, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK6 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This NEK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-39 amino acids from the N-terminal region of human NEK6.

Clone: RB2965

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-NEK6 (ABIN1882104)

Takeno, Takemasa, Doki, Yamasaki, Miyata, Takiguchi, Fujiwara, Matsubara, Monden: "Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis." dans: British journal of cancer, Vol. 99, Issue 8, pp. 1307-15, (2008) (PubMed).

Belham, Roig, Caldwell, Aoyama, Kemp, Comb, Avruch: "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases." dans: The Journal of biological chemistry, Vol. 278, Issue 37, pp. 34897-909, (2003) (PubMed).

Lizcano, Deak, Morrice, Kieloch, Hastie, Dong, Schutkowski, Reimer, Alessi et al.: "Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and ..." dans: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 27839-49, (2002) (PubMed).

Hashimoto, Akita, Hibino, Kohri, Nakanishi: "Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase." dans: Biochemical and biophysical research communications, Vol. 293, Issue 2, pp. 753-8, (2002) (PubMed).

Détails sur NEK6

Antigène: NEK6 (NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6))

Autre désignation: NEK6 (NEK6 Produits)

Synonymes: anticorps 1300007C09Rik, anticorps si:ch211-167p9.4, anticorps ATNEK5, anticorps MOE17.17, anticorps NIMA-RELATED KINASE5, anticorps NIMA-related kinase 5, anticorps SID6-1512, anticorps NIMA (never in mitosis gene a)-related expressed kinase 6, anticorps NIMA-related kinase 6, anticorps NIMA related kinase 6, anticorps Serine/Threonine kinase catalytic domain protein, anticorps NIMA-related kinase 6 S homeolog, anticorps Nek6, anticorps nek6, anticorps NEK6, anticorps NEK5, anticorps nek6.S

Sujet: NEK6 is a serine/threonine kinase that controls initiation of mitosis. NEK6 is activated during M phase. It is required for chromosome segregation at metaphase-anaphase transition and therefore for mitotic progression. Inhibition of activity results in apoptosis.

Poids moléculaire: 35714

NCBI Accession: NP_001138473, NP_001159639, NP_001159640, NP_001159641, NP_001159642, NP_001159643, NP_055212

UniProt: Q9HC98