Caspase 8 anticorps (AA 1-227)

N° du produit ABIN1885811

L’anticorps Lapin Polyclonal anti-Caspase 8 a été validé pour WB, IHC et IF. Il convient pour détecter Caspase 8 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Caspase 8 anticorps (AA 1-227) (ABIN1885811)

Antigène: Caspase 8 (CASP8)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Caspase 8 anticorps

Épitope: AA 1-227

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 227 of Human CASP8

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: caspase-8

Sujet: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit.Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits.This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli.The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD.This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.[provided by RefSeq]

Poids moléculaire: 58 kDa

ID gène: 841

NCBI Accession: NP_001219, NM_001228

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades