Caspase 12 anticorps (AA 2-17)

N° du produit ABIN1886847

Détail du produit anti-Caspase 12 anticorps

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Épitope: AA 2-17

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 12 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: Peptide corresponding to amino acids 2 to 17 of murine caspase-12.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur Caspase 12

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Autre désignation: Caspase-12 (CASP12 Produits)

Synonymes: anticorps Caspase-12, anticorps CASP-12, anticorps CASP12P1, anticorps caspase 12, anticorps caspase 12 (gene/pseudogene), anticorps Casp12, anticorps CASP12

Sujet: Three distinct signaling pathways lead to programmed cell death (apoptosis).The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved.The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved.Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion.Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis.Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP).Caspase-12 mediates cytotoxicity induced by amyloid-beta.Caspase-12 is ubiquitously expressed in mouse tissues.
Synonyms: Casp-12

Pathways: Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response