AIF anticorps (AA 593-606)

N° du produit ABIN1886890

Cet anticorps Lapin Polyclonal détecte spécifiquement AIF dans WB, ELISA et ICC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour AIF anticorps (AA 593-606) (ABIN1886890)

Antigène: AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIF est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-AIF anticorps

Épitope: AA 593-606

Purification: Affinity chromatography purified via peptide column

Immunogène: Peptide corresponding to amino acids 593 to 606 of human AIF.This sequence is identical to those of mouse and rat AIF.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur AIF

Antigène: AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))

Autre désignation: AIF

Sujet: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation.These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins.A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF).Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria.AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9.AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection.AIF is highly conserved between human and mouse and widely expressed.

Poids moléculaire: 67 kDa

UniProt: O95381

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, L'effet Warburg