NPAS3 anticorps (Center)

N° du produit ABIN1887738

Détail du produit anti-NPAS3 anticorps

Antigène: NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPAS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 28 amino acid peptide from near the center of human NPAS3.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur NPAS3

Antigène: NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))

Autre désignation: NPAS3 (NPAS3 Produits)

Synonymes: anticorps trh, anticorps mop6, anticorps pasd6, anticorps MGC145768, anticorps MOP6, anticorps PASD6, anticorps bHLHe12, anticorps 4930423H22Rik, anticorps neuronal PAS domain protein 3, anticorps npas3, anticorps NPAS3, anticorps Npas3

Sujet: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia.It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region.NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities.Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin.These results demonstrate the essential role played by NPAS3 during structural and functional brain development.At least three isoforms of NPAS3 are known to exist.
Synonyms: Neuronal PAS domain-containing protein 3, member of Pas protein 6, MOP6

UniProt: Q8IXF0