ATP2C2 anticorps (N-Term)

N° du produit ABIN1888109

Détail du produit anti-ATP2C2 anticorps

Antigène: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP2C2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Réactivité croisée (Details): At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the amino terminus of human ATP2C2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur ATP2C2

Antigène: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Autre désignation: ATP2C2 (ATP2C2 Produits)

Synonymes: anticorps KIAA0703, anticorps MGC146612, anticorps SPCA2, anticorps 1810010G06Rik, anticorps Spca2, anticorps mKIAA0703, anticorps ATPase secretory pathway Ca2+ transporting 2, anticorps ATPase, Ca++ transporting, type 2C, member 2 S homeolog, anticorps ATPase, Ca++ transporting, type 2C, member 2, anticorps ATP2C2, anticorps atp2c2.S, anticorps atp2c2, anticorps Atp2c2

Sujet: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases.This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen.Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation.Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Synonyms: Calcium-transporting ATPase type 2C member 2, PMR1, SPCA2, hSPCA2

NCBI Accession: NP_055676

Pathways: Ribonucleoside Biosynthetic Process