SPG11 anticorps

N° du produit ABIN1888237

Détail du produit anti-SPG11 anticorps

Antigène: SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPG11 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide of human SPG11.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SPG11

Antigène: SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))

Autre désignation: SPG11 (SPG11 Produits)

Synonymes: anticorps 6030465E24Rik, anticorps A330015I11, anticorps C530005A01Rik, anticorps KIAA1840, anticorps RGD1562529, anticorps SPG11, spatacsin vesicle trafficking associated, anticorps Spg11, anticorps SPG11

Sujet: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.? Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration.Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC.Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage.It is expressed in all structures of the brain, with a high expression in the cerebellum.SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC.Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.? Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
Synonyms: Spastic paraplegia 11, colorectal carcinoma-associated protein, spatacsin