COL17A1 anticorps (Chain alpha 1)

N° du produit ABIN191526

Détail du produit anti-COL17A1 anticorps

Antigène: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Épitope: AA 507-548, Chain alpha 1

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COL17A1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Human type XVII Collagen / BP180 (aa 507-548).

Purification: Protein G Chromatography

Immunogène: Glutathione-S-transferase fusion protein containing the sequence of the immunodominant region of human type XVII collagen / BP180 (aa 507-548)

Information d'application

Indications d'application: ELISA: 1/5000. Western blot: 1/500. Immunocytochemistry on Frozen Sections: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in aqua bidest to a concentration of 1 mg/mL.

Concentration: 2.0 mg/mL

Buffer: 50 mM Tris, pH 7.4

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C and reconstituted at -20 °C.

Détails sur COL17A1

Antigène: COL17A1 (Collagen, Type XVII, alpha 1 (COL17A1))

Abstract: COL17A1 Produits

Synonymes: anticorps col17a1, anticorps fk89a06, anticorps si:ch211-223p8.6, anticorps wu:fk89a06, anticorps COL17A1, anticorps BA16H23.2, anticorps BP180, anticorps BPA-2, anticorps BPAG2, anticorps LAD-1, anticorps Bpag, anticorps Bpag2, anticorps collagen type XVII alpha 1 chain, anticorps collagen, type XVII, alpha 1b, anticorps collagen, type XVII, alpha 1, anticorps Col17a1, anticorps col17a1b, anticorps COL17A1

Sujet: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.Synonyms: 180 kDa bullous pemphigoid antigen 2, BP180, BPAG2, Bullous pemphigoid antigen 2, COL17A1, LABD97, LAD-1

ID gène: 1308

NCBI Accession: NP_000485

UniProt: Q9UMD9